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1

Glycosyltransferases, Important Tools for Drug Design

Luzhetskyy, Andriy, Mendez, Carmen, Salas, Jose, Bechthold, Andreas

Journal:

Current Topics in Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 702 KB

english, 2008

2

Biosynthesis of the Terpene Phenalinolactone in Streptomyces sp. Tü6071: Analysis of the Gene Cluster and Generation of Derivatives

Clemens Dürr, Hans-Jörg Schnell, Andriy Luzhetskyy, Renato Murillo, Monika Weber, Katrin Welzel, Andreas Vente, Andreas Bechthold

Journal:

Chemistry & Biology

Year:

2006

Language:

english

File:

PDF, 321 KB

english, 2006

3

Complete genome sequence of Streptomyces fulvissimus

Myronovskyi, M., Tokovenko, B., Manderscheid, N., Petzke, L., Luzhetskyy, A.

Journal:

Journal of Biotechnology

Year:

2013

Language:

english

File:

PDF, 272 KB

english, 2013

4

Characterization of the post-assembly line tailoring processes in teicoplanin biosynthesis

Yushchuk, Oleksandr, Ostash, Bohdan, Pham, Thu H., Luzhetskyy, Andriy, Fedorenko, Victor, Truman, Andrew W, Horbal, Liliya

Journal:

ACS Chemical Biology

Year:

2016

Language:

english

File:

PDF, 953 KB

english, 2016

5

A gene cluster for the biosynthesis of moenomycin family antibiotics in the genome of teicoplanin producerActinoplanes teichomyceticus

Horbal, Liliya, Ostash, Bohdan, Luzhetskyy, Andriy, Walker, Suzanne, Kalinowski, Jorn, Fedorenko, Victor

Journal:

Applied Microbiology and Biotechnology

Year:

2016

Language:

english

File:

PDF, 762 KB

english, 2016

6

Generation of new compounds through unbalanced transcription of landomycin A cluster

Myronovskyi, Maksym, Brötz, Elke, Rosenkränzer, Birgit, Manderscheid, Niko, Tokovenko, Bogdan, Rebets, Yuriy, Luzhetskyy, Andriy

Journal:

Applied Microbiology and Biotechnology

Year:

2016

Language:

english

File:

PDF, 615 KB

english, 2016

7

Native and engineered promoters in natural product discovery

Myronovskyi, Maksym, Luzhetskyy, Andriy

Journal:

Natural Product Reports

Year:

2016

Language:

english

File:

PDF, 841 KB

english, 2016

8

Design, development and application of whole-cell based antibiotic-specific biosensor

Rebets, Yuriy, Schmelz, Stefan, Gromyko, Oleksandr, Tistechok, Stepan, Petzke, Lutz, Scrima, Andrea, Luzhetskyy, Andriy

Journal:

Metabolic Engineering

Year:

2018

Language:

english

File:

PDF, 1.51 MB

english, 2018

9

Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds

Axenov-Gibanov, Denis V., Voytsekhovskaya, Irina V., Tokovenko, Bogdan T., Protasov, Eugeniy S., Gamaiunov, Stanislav V., Rebets, Yuriy V., Luzhetskyy, Andriy N., Timofeyev, Maxim A., Acharya, Krishne

Journal:

Year:

2016

Language:

english

File:

PDF, 409 KB

english, 2016

10

Generation of a cluster-free Streptomyces albus chassis strains for improved heterologous expression of secondary metabolite clusters

Myronovskyi, Maksym, Rosenkränzer, Birgit, Nadmid, Suvd, Pujic, Petar, Normand, Philippe, Luzhetskyy, Andriy

Journal:

Metabolic Engineering

Year:

2018

Language:

english

File:

PDF, 1.13 MB

english, 2018

11

Über das Acceptorsubstrat der C-Glycosyltransferase UrdGT2: drei Prejadomycin-C-glycoside aus einer konstruierten Mutante von Streptomyces globisporus 1912 ΔlndE(urdGT2)

Irfan Baig, Madan Kharel, Anton Kobylyanskyy, Lili Zhu, Yuriy Rebets, Bohdan Ostash, Andriy Luzhetskyy, Andreas Bechthold, Victor A. Fedorenko, Jürgen Rohr

Journal:

Angewandte Chemie

Year:

2006

Language:

german

File:

PDF, 234 KB

german, 2006

12

On the Acceptor Substrate of C-Glycosyltransferase UrdGT2: Three Prejadomycin C-Glycosides from an Engineered Mutant of Streptomyces globisporus 1912 ΔlndE(urdGT2)

Irfan Baig, Madan Kharel, Anton Kobylyanskyy, Lili Zhu, Yuriy Rebets, Bohdan Ostash, Andriy Luzhetskyy, Andreas Bechthold, Victor A. Fedorenko, Jürgen Rohr

Journal:

Angewandte Chemie International Edition

Year:

2006

Language:

english

File:

PDF, 234 KB

english, 2006

13

Function of lanGT3, a Glycosyltransferase Gene Involved in Landomycin A Biosynthesis

Andriy Luzhetskyy, Tao Liu, Marta Fedoryshyn, Bohdan Ostash, Viktor Fedorenko, Jürgen Rohr, Andreas Bechthold

Journal:

Year:

2004

Language:

english

File:

PDF, 126 KB

english, 2004

14

Generation of Novel Landomycins M and O through Targeted Gene Disruption

Andriy Luzhetskyy, Lili Zhu, Miranda Gibson, Marta Fedoryshyn, Clemens Dürr, Carsten Hofmann, Dirk Hoffmeister, Bohdan Ostash, Cynthia Mattingly, Val Adams, Victor Fedorenko, Jürgen Rohr, Andreas Bech

Journal:

Year:

2005

Language:

english

File:

PDF, 86 KB

english, 2005

15

LanGT2 Catalyzes the First Glycosylation Step during Landomycin A Biosynthesis

Andriy Luzhetskyy, Takaaki Taguchi, Marta Fedoryshyn, Clemens Dürr, Sven-Eric Wohlert, Volodymyr Novikov, Andreas Bechthold

Journal:

Year:

2005

Language:

english

File:

PDF, 102 KB

english, 2005

16

LanV, a Bifunctional Enzyme: Aromatase and Ketoreductase during Landomycin A Biosynthesis

Almuth Mayer, Takaaki Taguchi, Anton Linnenbrink, Carsten Hofmann, Andriy Luzhetskyy, Andreas Bechthold

Journal:

Year:

2005

Language:

english

File:

PDF, 101 KB

english, 2005

17

Generation of New Landomycins with Altered Saccharide Patterns through Over-expression of the Glycosyltransferase Gene lanGT3 in the Biosynthetic Gene Cluster of Landomycin A in Streptomyces cyanogenus S-136

Lili Zhu, Andriy Luzhetskyy, Martha Luzhetska, Cynthia Mattingly, Val Adams, Andreas Bechthold, Jürgen Rohr

Journal:

Year:

2007

Language:

english

File:

PDF, 120 KB

english, 2007

18

Cloning and Heterologous Expression of the Aranciamycin Biosynthetic Gene Cluster Revealed a New Flexible Glycosyltransferase

Andriy Luzhetskyy, Almuth Mayer, Jens Hoffmann, Stefan Pelzer, Meike Holzenkämper, Bettina Schmitt, Sven-Eric Wohlert, Andreas Vente, Andreas Bechthold

Journal:

Year:

2007

Language:

english

File:

PDF, 78 KB

english, 2007

19

Cloning and Sequencing of the Biosynthetic Gene Cluster for Saquayamycin Z and Galtamycin B and the Elucidation of the Assembly of Their Saccharide Chains

Annette Erb, Andriy Luzhetskyy, Uwe Hardter, Andreas Bechthold

Journal:

Year:

2009

Language:

english

File:

PDF, 498 KB

english, 2009

20

Generation of New Landomycins by Combinatorial Biosynthetic Manipulation of the LndGT4 Gene of the Landomycin E Cluster in S. globisporus

Bohdan Ostash, Uwe Rix, Lily L.Remsing Rix, Tao Liu, Felipe Lombo, Andriy Luzhetskyy, Oleksandr Gromyko, Chenchen Wang, Alfredo F Braña, Carmen Méndez, José A Salas, Victor Fedorenko, Jürgen Rohr

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 628 KB

english, 2004

21

Iteratively Acting Glycosyltransferases Involved in the Hexasaccharide Biosynthesis of Landomycin A

Andriy Luzhetskyy, Marta Fedoryshyn, Clemens Dürr, Takaaki Taguchi, Volodymyr Novikov, Andreas Bechthold

Journal:

Chemistry & Biology

Year:

2005

Language:

english

File:

PDF, 148 KB

english, 2005

22

Engineering a Function into a Glycosyltransferase

Christine Krauth, Marta Fedoryshyn, Christian Schleberger, Andriy Luzhetskyy, Andreas Bechthold

Journal:

Chemistry & Biology

Year:

2009

Language:

english

File:

PDF, 962 KB

english, 2009

23

Rational Design of an Aryl-C-Glycoside Catalyst from a Natural Product O-Glycosyltransferase

Johannes Härle, Stefan Günther, Benjamin Lauinger, Monika Weber, Bernd Kammerer, David L. Zechel, Andriy Luzhetskyy, Andreas Bechthold

Journal:

Chemistry & Biology

Year:

2011

Language:

english

File:

PDF, 1.16 MB

english, 2011

24

Production of landomycins in Streptomyces globisporus 1912 and S. cyanogenus S136 is regulated by genes encoding putative transcriptional activators

Y. Rebets, B. Ostash, A. Luzhetskyy, D. Hoffmeister, A. Braňa, C. Mendez, J.A. Salas, A. Bechthold, V. Fedorenko

Journal:

FEMS Microbiology Letters

Year:

2003

Language:

english

File:

PDF, 197 KB

english, 2003

25

Expression of the landomycin biosynthetic gene cluster in a PKS mutant of Streptomyces fradiae is dependent on the coexpression of a putative transcriptional activator gene

Ursula von Mulert, Andriy Luzhetskyy, Carsten Hofmann, Almuth Mayer, Andreas Bechthold

Journal:

FEMS Microbiology Letters

Year:

2004

Language:

english

File:

PDF, 449 KB

english, 2004

26

SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors

Liliya Horbal, Yuriy Rebets, Mariya Rabyk, Roman Makitrynskyy, Andriy Luzhetskyy, Victor Fedorenko, Andreas Bechthold

Journal:

Year:

2012

Language:

english

File:

PDF, 803 KB

english, 2012

27

Targeted disruption ofStreptomyces globisporus lndFandlndLcyclase genes involved in landomycin E biosynthesis

B. Ostash, Y. Rebets, V. Yuskevich, A. Luzhetskyy, V. Tkachenko, V. Fedorenko

Journal:

Folia Microbiologica

Year:

2003

Language:

english

File:

PDF, 612 KB

english, 2003

28

Function oflanIin regulation of landomycin A biosynthesis inStreptomyces cyanogenusS136 and cross-complementation studies withStreptomycesantibiotic regulatory proteins encoding genes

Yuriy Rebets, Lilia Dutko, Bohdan Ostash, Andriy Luzhetskyy, Olexandr Kulachkovskyy, Toshio Yamaguchi, Tatsunosuke Nakamura, Andreas Bechthold, Victor Fedorenko

Journal:

Archives of Microbiology

Year:

2008

Language:

english

File:

PDF, 456 KB

english, 2008

29

A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis

Andriy Luzhetskyy, Holger Weiss, Annette Charge, Elisabeth Welle, Anton Linnenbrink, Andreas Vente, Andreas Bechthold

Journal:

Applied Microbiology and Biotechnology

Year:

2007

Language:

english

File:

PDF, 234 KB

english, 2007

30

Functional expression of the Cre recombinase in actinomycetes

Marta Fedoryshyn, Elisabeth Welle, Andreas Bechthold, Andriy Luzhetskyy

Journal:

Applied Microbiology and Biotechnology

Year:

2008

Language:

english

File:

PDF, 151 KB

english, 2008

31

Aranciamycin analogs generated by combinatorial biosynthesis show improved antitumor activity

Andriy Luzhetskyy, Jens Hoffmann, Stefan Pelzer, Sven-Eric Wohlert, Andreas Vente, Andreas Bechthold

Journal:

Applied Microbiology and Biotechnology

Year:

2008

Language:

english

File:

PDF, 132 KB

english, 2008

32

Features and applications of bacterial glycosyltransferases: current state and prospects

Andriy Luzhetskyy, Andreas Bechthold

Journal:

Applied Microbiology and Biotechnology

Year:

2008

Language:

english

File:

PDF, 191 KB

english, 2008

33

Differences in the substrate specificity of glycosyltransferases involved in landomycins A and E biosynthesis

Annette Erb, Christine Krauth, Andriy Luzhetskyy, Andreas Bechthold

Journal:

Applied Microbiology and Biotechnology

Year:

2009

Language:

english

File:

PDF, 584 KB

english, 2009

34

In vivo Tn5-based transposon mutagenesis of Streptomycetes

Lutz Petzke, Andriy Luzhetskyy

Journal:

Applied Microbiology and Biotechnology

Year:

2009

Language:

english

File:

PDF, 244 KB

english, 2009

35

Characterization and analysis of the regulatory network involved in control of lipomycin biosynthesis inStreptomyces aureofaciensTü117

Liliya Horbal, Yuriy Rebets, Maria Rabyk, Andriy Luzhetskyy, Bogdan Ostash, Elisabeth Welle, Tatsunosuke Nakamura, Victor Fedorenko, Andreas Bechthold

Journal:

Applied Microbiology and Biotechnology

Year:

2010

Language:

english

File:

PDF, 275 KB

english, 2010

36

Erratum to: In vivo Tn5-based transposon mutagenesis of Streptomycetes

Lutz Petzke, Andriy Luzhetskyy

Journal:

Applied Microbiology and Biotechnology

Year:

2010

File:

PDF, 44 KB

2010

37

I-SceI endonuclease: a new tool for DNA repair studies and genetic manipulations in streptomycetes

Theresa Siegl, Lutz Petzke, Elisabeth Welle, Andriy Luzhetskyy

Journal:

Applied Microbiology and Biotechnology

Year:

2010

Language:

english

File:

PDF, 259 KB

english, 2010

38

The Use of PCR for Detecting Genes That Encode Type I Polyketide Synthases in Genomes of Actinomycetes

B. E. Ostash, S. V. Ogonyan, A. N. Luzhetskyy, A. Bechthold, V. A. Fedorenko

Journal:

Russian Journal of Genetics

Year:

2005

Language:

english

File:

PDF, 80 KB

english, 2005

39

It works: combinatorial biosynthesis for generating novel glycosylated compounds

Andriy Luzhetskyy, Andreas Bechthold

Journal:

Molecular Microbiology

Year:

2005

Language:

english

File:

PDF, 160 KB

english, 2005

40

A putative proteinase gene is involved in regulation of landomycin E biosynthesis in Streptomyces globisporus 1912

Lilia Dutko, Yuriy Rebets, Bohdan Ostash, Andriy Luzhetskyy, Andreas Bechthold, Tatsunosuke Nakamura, Victor Fedorenko

Journal:

FEMS Microbiology Letters

Year:

2006

Language:

english

File:

PDF, 145 KB

english, 2006

41

Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136

Iryna Ostash, Bohdan Ostash, Andriy Luzhetskyy, Andreas Bechthold, Suzanne Walker, Victor Fedorenko

Journal:

FEMS Microbiology Letters

Year:

2008

Language:

english

File:

PDF, 283 KB

english, 2008

42

IncP plasmids are most effective in mediating conjugation betweenEscherichia coliand streptomycetes

A. Luzhetskyy, M. Fedoryshyn, O. Gromyko, B. Ostash, Y. Rebets, A. Bechthold, V. Fedorenko

Journal:

Russian Journal of Genetics

Year:

2006

Language:

english

File:

PDF, 208 KB

english, 2006

43

Properties oflanK-based regulatory circuit involved in landomycin biosynthesis inStreptomyces cyanogenusS136

B. Ostash, I. Ostash, L. Zhu, M. K. Kharel, A. Luzhetskyy, A. Bechthold, S. Walker, J. Rohr, V. Fedorenko

Journal:

Russian Journal of Genetics

Year:

2010

Language:

english

File:

PDF, 328 KB

english, 2010

44

Pimprinols A–C, from the terrestrial actinomycete, Streptomyces sp.

Ritesh Raju, Oleksandr Gromyko, Viktor Fedorenko, Andriy Luzhetskyy, Rolf Müller

Journal:

Tetrahedron Letters

Year:

2012

Language:

english

File:

PDF, 242 KB

english, 2012

45

Actinomycetes genome engineering approaches

Theresa Siegl, Andriy Luzhetskyy

Journal:

Antonie van Leeuwenhoek

Year:

2012

Language:

english

File:

PDF, 655 KB

english, 2012

46

ChemInform Abstract: Pimprinols A—C, from the Terrestrial Actinomycete, Streptomyces sp.

Ritesh Raju, Oleksandr Gromyko, Viktor Fedorenko, Andriy Luzhetskyy, Rolf Mueller

Journal:

Year:

2012

File:

PDF, 21 KB

2012

47

Marker removal from actinomycetes genome using Flp recombinase

Marta Fedoryshyn, Lutz Petzke, Elisabeth Welle, Andreas Bechthold, Andriy Luzhetskyy

Journal:

Year:

2008

Language:

english

File:

PDF, 234 KB

english, 2008

48

Juniperolide A: A New Polyketide Isolated from a Terrestrial Actinomycete, Streptomyces sp.

Raju, Ritesh, Gromyko, Oleksandr, Fedorenko, Viktor, Luzhetskyy, Andriy, Plaza, Alberto, Müller, Rolf

Journal:

Organic Letters

Year:

2012

Language:

english

File:

PDF, 389 KB

english, 2012

49

Cloning, purification and characterization of a functional anthracycline glycosyltransferase

Giorgos Sianidis, Sven-Eric Wohlert, Charalambos Pozidis, Spyridoula Karamanou, Andriy Luzhetskyy, Andreas Vente, Anastassios Economou

Journal:

Journal of Biotechnology

Year:

2006

Language:

english

File:

PDF, 415 KB

english, 2006

50

Surprising production of a new urdamycin derivative by S. fradiae ΔurdQ/R

M. Fedoryshyn, M. Nur-e-Alam, L. Zhu, A. Luzhetskyy, J. Rohr, A. Bechthold

Journal:

Journal of Biotechnology

Year:

2007

Language:

english

File:

PDF, 512 KB

english, 2007